Probing the Interactions of Sulfur-Containing Histidine Compounds with Human Gamma-Glutamyl Transpeptidase
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چکیده
منابع مشابه
The reaction of glutathione with amino acids and related compounds as catalyzed by gamma-glutamyl transpeptidase.
In a previous publication (1) methods were described which permit the quantitative estimation of the action of y-glutamyl transpeptidase upon glutathione. In the present report these methods are employed to study the influence of amino acids. pcptides, and other compounds upon the reaction. In addition, we present the results of attempts to account for all the main products formed in the reacti...
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Introduction The enzyme gamma-glutamyl transpeptidase (GGT)* is widely used as a marker in preneoplastic lesions in the liver during chemical carcinogenesis (1). The discovery of a link between GGT and liver carcinogenesis first occurred in 1972 when Fiala and co-workers reported elevated levels of the enzyme in livers of rats fed the hepatocarcinogen 3'-methyl-4dimethylaminoazobenzene and also...
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Gamma-glutamyl transpeptidase (GGT, EC 2.3.2.2) a membrane-associated enzyme is a main regulator of glutathione (GSH) levels. The enzyme is not only the inhibitor of apoptosis induced by oxidative stress, but it is engaged in anti-tumor drug cell resistance and is considered as a marker for neoplastic changes, cell differentiation and aging. The surface and total activities of GGT in unfixed, f...
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Gamma glutamyl transpeptidase (GGT) is a transferase, which is of great importance in sustaining intracellular cysteine and glutathione levels. The abnormal expression of GGT is significantly associated with features of many metabolic syndromes (e.g., hepatocellular carcinoma). Therefore, it is essential to develop methods to detect GGT so as to monitor the physiological or pathological phenome...
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ژورنال
عنوان ژورنال: Marine Drugs
سال: 2019
ISSN: 1660-3397
DOI: 10.3390/md17120650